Synthesis and Functional Characterization of Substituted Isoquinolinones as MT2-Selective Melatoninergic Ligands
Figure 6
Isoquinolinone derivative-induced inhibition of forskolin-stimulated cAMP production.
CHO cells expressing MT1 or MT2 were treated with 50 µM forskolin and increasing concentrations of individual tested compounds as indicated at the lower left corner of each plot. All the responses were expressed as the percentage of that induced by forskolin alone (as 100%). Estimation of maximal inhibition and IC50 were tabulated in Table 3.