Cryptoporus volvatus Extract Inhibits Influenza Virus Replication In Vitro and In Vivo
Figure 5
Characterization of Cryptoporus volvatus extract efficacy in a mouse model of H1N1/09 influenza virus infection.
(A) Survival rate and (B) Weight changes of mice. The dashed line indicates 75% of initial body weight, and data are presented as mean ±SD. Mice infected with or without H1N1/09 influenza virus were treated with the extract or with saline. Each group contained five BALB/c mice. Body weight and survival status were checked daily. Mice were euthanized upon the loss of 25% of their initial body weight. normal saline (no virus as negative control group); 50 µg/g (no virus as extract control group); BJ09/normal saline (virus infection (103.5 pfu) control group); BJ09/16.5 µg/g (virus infection (103.5 pfu) and treated with low-dosage extract group); BJ09/50 µg/g (virus infection (103.5 pfu) and treated with high-dosage extract group). Data are presented as mean ±SD.