Determination of Morphological, Biometric and Biochemical Susceptibilities in Healthy Eurasier Dogs with Suspected Inherited Glaucoma
Figure 5
Determinations of biomarkers of oxidative stress in the plasma of Eurasier dogs.
(a) Plasma glutathione peroxidase (GP) activity in all EDs (black bar), compared with a cohort of randomized control dogs (white bar). (b) Measurement of plasma taurine concentrations in EDs (black bar), compared with control dogs (white bar). (c-d) Determination of the concentrations of the taurine's precursors, methionine and cysteine, in plasma from EDs (black bar) and control dogs (white bar). (e): Measurement of plasma GP activity in the various subgroups of the ED cohort. (f): Measurement of plasma taurine concentration in the various subgroups of EDs. (g) Correlation between GP activity and plasma taurine concentration in the adult male subgroup of EDs, demonstrating a significant association of low levels of GP activity with a low plasma taurine concentration (p<0.05; Spearman's correlation test). This correlation was shown to be linear (r2>0.52). ***p<0.001 versus the control dogs (Mann Whitney test for a, b,c and Kruskal-Wallis ANOVA followed by the Dunn's post-hoc test for d, e, f).