Altered Clock Gene Expression in Obese Visceral Adipose Tissue Is Associated with Metabolic Syndrome
Figure 1
24 h of clock gene expression profiles in human adipocytes from lean and obese subjects.
Circadian clock gene expression in adipocytes from lean (full line) and obese (dashed line) subjects. (A) CLOCK gene expression. (B) BMAL1 gene expression. (C) PER1 gene expression (D) PER2 gene expression (E) CRY1 gene expression (F) CRY2 gene expression (G) ROR ALPHA gene expression. (H) REV-ERB ALPHA gene expression. *p<0.05; **p<0.01; ***p<0.001; Data are expressed as mean ±S.E.M of n = 10–15. The relative expression of clock genes is calculated and normalized by 36B4 house keeping gene. Time = Time in culture after serum shock treatment.