A Critical Role of CDKN3 in Bcr-Abl-Mediated Tumorigenesis
Figure 3
CDKN3 deficiency promotes K562 xenografted tumor growth in nude mice.
(A) Nude mice were subcutaneously injected with K562 cells stably expressing sh-CDKN3 or sh-luc (control). The tumor volumes were measured at indicated time points. Plotted are results from three independent experiments. Error bars, SEM; n = 9; *P<0.05. (B) Tumors were excised from mice. Shown are representative images from four independent experiments with similar results. (C) Relative volume of tumors excised from nude mice injected with K562 cells expressing sh-luc (control) or sh-CDKN3. The average volume of control tumors is set to 100%. Error bars, SEM; n = 9; *P<0.05.