COMP-Angiopoietin1 Potentiates the Effects of Bone Morphogenic Protein-2 on Ischemic Necrosis of the Femoral Head in Rats
Figure 2
Histologic findings of sham and infarcted femoral heads.
(A and B) As compared with the sham-operated group, bone marrow of the femoral heads in the BSA group was necrotic and most of the articular cartilage had been destroyed and replaced by fibrous tissue, as seen on H&E staining (A) and Safranin-O staining (B). Femoral heads in the BMP-2 group showed more obvious deformity and more damaged articular cartilage compared with the sham and COMP-Ang1 + BMP-2 groups. Femoral heads in the COMP-Ang1 + BMP-2 group exhibited relatively well-preserved morphologies. (C and D) The degree of damage to the femoral head was scored from zero to five. The number in each image is the damage score. Femoral heads of the BSA and BMP-2 group had higher damage scores. Damage scores were significantly lower in the COMP-Ang1 + BMP-2 group compared with BSA and BMP-2 groups. **p<0.01 vs. BSA or BMP-2.