Association of ITPA Genotype with Event-Free Survival and Relapse Rates in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy
Figure 3
Influence of ITPA genotype on the incidence of relapses grouped according to time to relapse.
Pie chart slices represent the percent of patients with different ITPA genotypes; wild-type ITPA: 94CC/IVS2+21AA ITPA genotype combination, variant ITPA: 94CA/IVS2+21AA, 94CA/IVS2+21AC, 94CA/IVS2+21CC, 94CC/IVS2+21AC, 94CC/IVS2+21CC ITPA genotype combinations. Very early relapse, <18 months after diagnosis; early relapse,>18 months after diagnosis and <6 months after the end of treatment; late relapse,>6 months after discontinuation of therapy (multinomial regression model adjusted to treatment protocol group, age group at diagnosis and gender; reference category = no relapse; p = 0.003).