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Computational Modeling Reveals that a Combination of Chemotaxis and Differential Adhesion Leads to Robust Cell Sorting during Tissue Patterning
Figure 5
Chemotaxis coupled with delayed differential adhesion response yields optimal sorting in presence of noise.
(a) Fractional noise in the morphogen gradient for different values of 
. (Inset) Representative traces of morphogen concentration, 
, along 
for different values of 
. (b) Bar graphs of fraction of correct and stable sorting, 
(blue) and 
(red), respectively, for different values of 
at 
= 0.75 and 
= 0.25. 10 runs were performed for each value of 
. (c) Bar graphs of fraction of correct and stable sorting, 
(blue) and 
(red), respectively, for different values of jat 
= 0.25 and η = 10. 10 runs were performed for each value of 
. (d) Bar graphs of fraction of correct and stable sorting, 
(blue) and 
(red) respectively, for different values of 
at 
= 0.75 and 
= 0 for the first 500 MCS, followed by 
= 0.75 and 
= 1.5 for the subsequent 2000 MCS. 10 runs were performed for each value of 
. (e) Illustration for the chemotaxis coupled with delayed differential adhesion response model.
doi: https://doi.org/10.1371/journal.pone.0109286.g005