Targeting of Alpha-V Integrins Reduces Malignancy of Bladder Carcinoma
Figure 5
ITGAV knockdown in UM-UC-3luc2 cells affects intra-bone growth in a preclinical model.
A) Percentage of mice with tumors after intra-bone inoculation of either αv-kd-UM-UC-3luc2 or NT-UM-UC-3luc2 cells B) Total tumor burden of the mice injected with αv-kd-UM-UC-3luc2 (closed circles) or NT-UM-UC-3luc2 cells (open circles). C) Representative images of mice intra-osseously inoculated with either αv-kd-UM-UC-3luc2 or NT-UM-UC-3luc2 cells 7 days after inoculation (n = 10/group *P<0.05).