Adjuvant Potential of Selegiline in Attenuating Organ Dysfunction in Septic Rats with Peritonitis
Figure 4
Effects of selegiline on blood potassium concentration and metabolic acidosis.
Alterations in arterial blood levels of (A) pH, (B) bicarbonate (HCO3−), (C) carbon dioxide tension (PaCO2), and (D) base excess (BE) during the experimental period. Rats underwent sham operation (SOP), SOP plus selegiline administration (3 mg/kg, i.v., SOP + SEL), cecal ligation and puncture (CLP), or CLP plus SEL administration (3 mg/kg, i.v., CLP + SEL). Data are expressed as mean ± SEM, n = 10 in each group for all time-points. **p<0.01, CLP vs. SOP; †p<0.05 and ††p<0.01, with vs. without SEL in animals treated with CLP.