Adjuvant Potential of Selegiline in Attenuating Organ Dysfunction in Septic Rats with Peritonitis
Figure 3
Effects of selegiline on organ function.
Alterations in plasma levels of (A) alanine aminotransferase (ALT), (B) asparate aminotransferase (AST), (C) lactate dehydrogenase (LDH), (D) blood urea nitrogen (BUN), (E) creatinine, and (F) blood potassium concentration during the experimental period. Rats underwent sham operation (SOP), SOP plus selegiline administration (3 mg/kg, i.v., SOP + SEL), cecal ligation and puncture (CLP), or CLP plus SEL administration (3 mg/kg, i.v., CLP + SEL). Data are expressed as mean ± SEM, n = 10 in each group for all time-points. *p<0.05 and **p<0.01, CLP vs. SOP; †p<0.05 and ††p<0.01, with vs. without SEL in animals treated with CLP.