Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis
Figure 5
INT-767 inhibits systemic and local inflammation in ApoE−/− mice.
Serum A) IL-1β, B) IL-6, C) IL-8 and D) IL-12 levels in ApoE−/− mice treated with INT-767. E) Representative picture of immunofluorescence analysis of CD68-positive macrophages and MCP-1 in the aortas of ApoE−/− mice treated with INT-767. Quantification of immunofluorescence analysis of F) CD68 and G) MCP-1 in the aortas of ApoE−/− mice treated with INT-767. H) mRNA levels of aortic cytokines and chemokines in ApoE−/− mice treated with INT-767. I) NF-κB binding activity in the aortas of ApoE−/− mice treated with INT-767. *P<0.05, **P<0.001 and ***P<0.001.