In Vivo Evidence for Platelet-Induced Physiological Angiogenesis by a COX Driven Mechanism
Figure 5
VEGF overexpression cannot rescue angiogenic deficit.
A) Extensor digitorum longus muscle VEGF expression in wildtype and MUC1-VEGF mice. MUC1-VEGF human VEGF (•) plus mouse VEGF (○) resulted in a 45% increase in total content (▪) vs. wildtype. B) MUC1-VEGF mice had higher initial C∶F than wildtype. Capillary sprouting with or without platelets was no different from wildtype. *P<0.05 vs. C57 BL/6 controls, +P<0.05 vs. contralateral.