Knock-Down of IL-1Ra in Obese Mice Decreases Liver Inflammation and Improves Insulin Sensitivity
Figure 4
IL-1Ra ASO treatment results in increased energy expenditure.
Oxygen consumption (A) and energy expenditure (B) were measured in CLAMS cages over a 48 hr period in week 4 of the study. core body temperature (C) in HFD-fed IL-1Ra ASO treated mice compared with control ASO treated mice. D) Activity is unchanged between groups. E) Quantitative PCR analysis of uncoupling protein 1 (UCP-1) in BAT. * p<0.05 compared to HFD-fed control treated group, n = 5 mice per group, ns, not significant.