Mangiferin Attenuates Diabetic Nephropathy by Inhibiting Oxidative Stress Mediated Signaling Cascade, TNFα Related and Mitochondrial Dependent Apoptotic Pathways in Streptozotocin-Induced Diabetic Rats
Figure 8
Mangiferin inhibits STZ-induced activation of MAPKs (Immunoblot analysis).
β actin was used as an internal control. Cont: normal control, Mang: treated with mangiferin, STZ: STZ-induced (diabetic), STZ+Mang: Mangiferin treated post to STZ-induced. MAPKs (p38, JNK and ERK1/2) expressions. Each column represents mean ± SEM, n = 6. “a” indicates the significant difference between the normal control and STZ-induced groups, “b” indicates the significant difference between the STZ-induced and mangiferin treated groups and “c” indicates the significant difference between the STZ+Mangiferin group and normal control group (Pa<0.05, Pb<0.05, Pc<0.05).