Therapeutic Benefits of Delayed Lithium Administration in the Neonatal Rat after Cerebral Hypoxia-Ischemia
Figure 1
Lithium treatment reduced HI brain injury.
A. The study design. B. Representative MAP2 staining from the dorsal hippocampus (left panels) and striatum (right panels) 12 weeks post-HI in vehicle-treated (upper panels) and lithium-treated rats (lower panels). C. The total volume of tissue loss 12 weeks after HI was reduced by 38.8% in lithium-treated mice (n = 23) compared with vehicle-treated mice (n = 21). D. The total pathological score. E. Neuropathological scores revealed less injury in the observed brain regions (except the hippocampus) after lithium treatment. Cx = cortex, Hip = hippocampus, Str = striatum, and Tha = thalamus; *p<0.05, **p<0.01.