Islet Autoimmunity Identifies a Unique Pattern of Impaired Pancreatic Beta-Cell Function, Markedly Reduced Pancreatic Beta Cell Mass and Insulin Resistance in Clinically Diagnosed Type 2 Diabetes
Figure 2
Beta cell mass (expressed as percentage of mean of donors without diabetes mellitus) in T2DM without autoimmune markers [mean 67.70±SEM 13.58 (n = 11) and T2DM with autoimmune markers (mean 12.80±SEM 4.54 (n = 4)] (p = 0.05) Amongst the donors with markers of autoimmune diabetes 4 out of 4 expressed pattern A pathology while among the donors without autoimmune markers, 3 out of 11 expressed pattern B pathology (p = 0.026).