Local and Systemic RAGE Axis Changes in Pulmonary Hypertension: CTEPH and iPAH
Figure 2
RAGE and HMGB1 expression on endothelial cells of regular PA and endarterectomised tissues.
Representative examples of 12 examined patients are shown. Immunohistochemical analysis of regular main pulmonary artery with RAGE expression on endothelium and smooth muscle cells is shown (A). Scale bar: 40 µm. RAGE expressing endothelial cells in vessel-like structures recanalizing the matrix of distal PEA material (B). Endothelial cells expressing RAGE in proximal PEA tissue (arrows point at neointima, C) and HMGB1 (* in recanalizing vessel-like structures, D) in distal PEA specimen are displayed. Scale bar: 20 µm. RAGE receptor for advanced glycation endproducts, HMGB1 high mobility group box 1, PA pulmonary artery, PEA pulmonary endarterectomy.