Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease
Figure 3
Inflammatory pathways are overrepresented by age-dependent gene expression changes in rTg4510 animals.
The 139 genes whose expression change with age in rTg4510 animals were subjected to Ingenuity Pathway Analysis. The top axis represents the –log(p-value) of the probability that the gene set represented the canonical pathway by chance, as determined by the Fisher’s Exact Test, with the red line delineating p = 0.05 threshold, and the bottom axis represents the ratio of the number of genes from the query gene set in the pathway to the total number of genes in the pathway. The top canonical pathways, shown by the blue bars, significantly overrepresented by these genes fell predominantly in pathways involved in inflammatory responses, as indicated by the red asterices. The green bars show that these genes also significantly overlap with gene expression modules affected in AD [14]. Gene expression modules identified by weighted gene correlation network analysis (WGCNA) are named by assigning arbitrary colors [11], in this case gold, light cyan and yellow. The genes that fell into these pathways are shown in Table S3 in File S1.