Impact of Age-Dependent Adventitia Inflammation on Structural Alteration of Abdominal Aorta in Hyperlipidemic Mice
Figure 1
Impact of age on the structure of the aorta in wild-type and apo E−/− mice.
(A–C) Atheromatous plaque area (A), elastin area (B), and collagen deposition (C) at each age and aorta region in apo E−/− and wild-type mice. (D–F) Representative images of hematoxylin–eosin (D), Victoria blue (E), and picrosirius red (F) staining in the abdominal aorta of apo E–/– mice at 52 weeks. Data are expressed as mean ± SEM [16 weeks: wild-type (n = 9), apo E–/– mice (n = 5–6); 32 weeks: wild-type (n = 5–7), apo E–/– mice (n = 6–7); 52 weeks: wild-type (n = 10), apo E–/–- mice (n = 9–11)]. **p<0.01, ***p<0.001 vs. wild-type mice. Scale bar, 100 µm.