Non-Classical ProIL-1beta Activation during Mammary Gland Infection Is Pathogen-Dependent but Caspase-1 Independent
Figure 2
Differential mammary innate immune response post-IMI with E. coli versus S. aureus.
(A) Local TNF-alpha, IL-1alpha, and MCP-1 concentrations in lactating mammary glands compared to mammary glands post-IMI with E. coli, S. aureus or sham-inoculated (PBS). (B) Local IL-6 concentrations in lactating mammary glands compared to mammary glands post-IMI with E. coli or S. aureus or sham-inoculated (PBS) mice. (C) Local concentrations of active IL-1beta in lactating mammary glands compared to mammary glands post-IMI with E. coli, S. aureus or sham-inoculated (PBS) mice. Letters of homogeneous subsets were marked if the difference between treatments were statistically significant (P<0.001) (DL = detection limit).