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Model Specification and the Reliability of fMRI Results: Implications for Longitudinal Neuroimaging Studies in Psychiatry

Figure 2

Task Related Neural Activity at Time 2.

Plotted values represent t-statistics from the emotional-faces-minus-shapes contrast during the second testing occasion. Default pipeline: data were modeled as a block-design with a canonical hemodynamic response function (HRF); Flexible HRF pipeline: data were modeled as a mixed block/event design and temporal and dispersion derivatives were added to the design matrix as additional basis functions; mCompCor pipeline: data were modeled as a block design and a additional regressor was added to the design matrix to account for physiological noise in the global signal; Combined Flexible HRF and mCompCor pipeline: data were modeled as a mixed block/event design and both the Flexible HRF and mCompCor components were implemented.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0105169.g002