Clustering Nuclear Receptors in Liver Regeneration Identifies Candidate Modulators of Hepatocyte Proliferation and Hepatocarcinoma
Figure 4
Markers of hepatocyte proliferation and growth termination correlate with the top three NRs at RF analysis.
Trα, Fxrβ, and Pparβ/δ mRNA expression levels correlate negatively with Ccne1 (A) and cMyc (B), and positively with Tgfβ1 (D); Fxrβ and Pparβ/δ, but not Trα, also correlate negatively with Pcna expression levels (C) (0.4>Pearson's correlation coefficient<−0.4; p<0.05). Legend: (white) quiescent; (black) proliferating; (▴) Sham; (▪) 0.5 days; (•) 1 day; (♦) 3 days; (▾) 7 days.