Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy
Figure 4
CSF-1R inhibition enhances CD8-mediated immunotherapy of melanoma.
(A) Tumor growth curves of individual mice are shown for the four different treatment groups. Immunotherapy is designated as ‘pept vacc’ and contains transfer of pmel-1 CD8 T cells and peptide vaccination. Numbers in the panels indicate the group size and the number of mice that are still alive at day 50. This experiment was repeated once with comparable outcome and indicated survival rates are compiled from both. (B) Average tumor sizes and standard error of the mean per group from experiment shown in panel (A). Statistical analysis was performed with two-way ANOVA after Bonferroni correction.