IL-17A Induces Pendrin Expression and Chloride-Bicarbonate Exchange in Human Bronchial Epithelial Cells
Figure 6
IL-17A-induced Pendrin expression is dependent on NF-κB.
Cells were incubated with NF-κB inhibitor II (20 µM) for 6 hours and then with NF-κB inhibitor II and IL-17A (10 ng/ml) for 24 h prior to analysis. Quantitative PCR (A) and immunoblotting (B) from normal HBE cells demonstrating that inhibition of NF-κB prevents IL-17A induced Pendrin expression.