Histone Acetyltransferase p300 Mediates Histone Acetylation of PS1 and BACE1 in a Cellular Model of Alzheimer's Disease
Figure 1
The expression levels of APP, PS1, BACE1 and Aβ were elevated in N2a/APPswe and N2a/APPwt cells.
(A) The expression of full length APP was increased in N2a/APPswe and N2a/APPwt cells compared to controls (vector-transfected). (B, C) mRNA and protein levels of PS1 and BACE1 were significantly elevated in N2a/APPswe and N2a/APPwt cells compared with control cells; (D) the downstream expression levels of Aβ1-42 and Aβ1-40 were significantly higher in N2a/APPswe and N2a/APPwt cells than control cells. *: P<0.05, as compared with N2a/APPwt cells, #: P<0.05, as compared with control cells (n = 3).