Evidence that RASSF1C Stimulation of Lung Cancer Cell Proliferation Depends on IGFBP-5 and PIWIL1 Expression Levels
Figure 9
Co-expression of RASSF1C-IGFBP5 sensitizes cells to betulinic acid
. H1299-BB, H1299-1C, H1299-1A-1C, and H1299-1C-BP5 cells were treated with betulinic acid (BA) for 24 h. Cells were then assayed for cell viability/proliferation. Cells co-expressing RASSF1C-IGFBP-5 were more sensitive to BA compared to cells over-expressing RASSF1C or co-expressing RASSF1A-RASSF1C. Data is representative of at least 3 independent experiments, and the values represent the mean±SEM. * P<0.05: for 1C compared to BB.