The Smn-Independent Beneficial Effects of Trichostatin A on an Intermediate Mouse Model of Spinal Muscular Atrophy
Figure 5
TSA treatment does not increase Smn protein levels.
(A) Western blot analyses were performed with specific antibodies against Smn in protein extracts from brains, spinal cords, hind limb muscle, hearts, or livers of Smn2B/- mice treated with either TSA or DMSO vehicle. Each lane represents one animal. β-tubulin or actin serve as a loading controls. (B) Quantification revealed no significant increase of Smn protein levels in brains, spinal cords, hind limb muscle, hearts, or livers of TSA-treated SMA mice (n = 3).