The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract
Figure 2
Systemic hMIC-1/GDF15 induces Fos immunoreactivity in brainstem nuclei.
Photomicrographs represent coronal sections (−3.5 mm from interaural line) of Fos immunoreactivity at 30, 60 or 120 min after systemic IP administration of a single dose of hMIC-1/GDF15 or vehicle. Scale bar: 40 µm. Abbreviations: DMX, dorsal motor nucleus of vagus; ap, area postrema; cc, central canal; NTS, nucleus of the solitary tract.