The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract
Figure 1
ICV administrated hMIC-1/GDF15 induces anorexia and weight loss.
A single injection of 50-1/GDF15 or vehicle was delivered ICV. Changes in body weight (A) and changes in food intake (B) were compared 16 hr post injection. Data expressed as mean ± s.e.m. Abbreviations: BW, body weight; FI, food intake.