Assessing the Efficacy of Nano- and Micro-Sized Magnetic Particles as Contrast Agents for MRI Cell Tracking
Figure 3
Confocal and electron microscopy images evidencing intracellular uptake and accumulation of contrast agents in lysosomes.
Cells were labelled with (A) Molday ION, (B) Feratrack or (C) Bangs Beads. Blue fluorescence corresponds to the nuclei, green to the contrast agents and red to LAMP2, scale bar represents 10 µm. Transmission electron microscopy was carried out without post-staining and electron dense (dark) areas correspond to the iron-oxide based contrast agents.