Human Retinal Transmitochondrial Cybrids with J or H mtDNA Haplogroups Respond Differently to Ultraviolet Radiation: Implications for Retinal Diseases
Figure 6
Schematic summary of the changes found in cybrids after UV treatment.
In response to identical UV conditions, cybrids with identical nuclei but different mtDNA haplogroups (H vs. J) showed differential responses of cell growth and expression patterns genes related to inflammation and apoptosis. After UV treatment, the J-treated cybrids had increased cell growth rates but a gene expression pattern consistent with higher levels of inflammation (elevated IL-33 and EFEMP1 along with decreased expression of CFH, a complement pathway inhibitor) compared to H-treated cybrids. The pro-apoptosis genes (RARA and BBC3) were expressed at a lower level in J-treated cybrids after UV treatment.