NGF and TERT Co-Transfected BMSCs Improve the Restoration of Cognitive Impairment in Vascular Dementia Rats
Figure 3
The results of the Morris water maze test in four groups.
In the positioning navigation test, the full-time average escape latency period and swimming distance of untransfected and NGF-TERT co-transfected BMSC transplanted VaD groups during three consecutive days were significantly shorter than those of the VaD group (Figure 3a). Escape period and swimming distance of the NGF-TERT co-transfected BMSC transplanted VaD group were significantly shorter than those of the untransfected BMSC transplanted VaD group (Figure 3b). In the space exploration test, the VaD rats treated with untransfected or NGF-TERT co-transfected BMSCs showed significantly longer swimming time in the original platform quadrant and significantly higher percentages of swimming distance in the original platform quadrant than those of the VaD group (Figure 3c). Additionally, the VaD rats treated with NGF-TERT co-transfected BMSCs exhibited significantly longer swimming times and distances in the original quadrant than the rats treated with untransfected BMSCs (Figure 3d) (*P<0.05).