Quantitative Characterization of Cell Behaviors through Cell Cycle Progression via Automated Cell Tracking
Figure 16
Correlation between direction of cell migration and cell long axis for MCF-10A and MDA-MB-231 cells.
The direction of cell long axis along cell trajectories is shown with green arrows. (A) For the MCF-10A cell, the direction of cell long axis is mostly perpendicular to the direction of the cell trajectory. (B) For the MDA-MB-231 cell, the direction of cell long axis is mostly parallel to that of the cell trajectory. As shown in the inset of figure A, we used the unit vector v1 and v2 to indicate the direction of cell long axis and the direction of migration, respectively. (C, D) The histograms of the angle between the two unit vectors are shown for MCF-10A and MDA-MB-231 cells, respectively. The majority of data points for the MDA-MB-231 cell are close to zero degree, while the data points for the MCF-10A cell are distributed between 0 and 90 degree.