The Effects of a Novel Hormonal Breast Cancer Therapy, Endoxifen, on the Mouse Skeleton
Figure 4
Micro-CT analysis of the femur in ovariectomized mice following 45 days of vehicle (Veh) or endoxifen (End) treatment.
A. The distal femur epiphysis, metaphysis and midshaft diaphysis are indicated and include bone volume/tissue volume, trabecular number, trabecular thickness, trabecular spacing, cross-sectional volume, cortical volume, marrow volume and cortical thickness. The mean ± SE are depicted. * denotes significance at P<0.05. B. Representative micro-CT images of the cancellous bone and cortical bone from the femur in a vehicle (control) and endoxifen treated animal are shown.