Dysregulated miR-361-5p/VEGF Axis in the Plasma and Endothelial Progenitor Cells of Patients with Coronary Artery Disease
Figure 2
smRNA-seq reveals candidate anti-VEGF miRNAs in both EPCs and the plasma of CAD patients.
(A) A Venn diagram showing overlapping miRNAs between smRNA-seq data and bioinformatics prediction results. (B) A table highlighting candidate VEGF-targeting miRNAs highly expressed in PB-EPCs. #: miRNAs known to target VEGF directly; arrows: miRNAs picked for further RT-qPCR validation. (C–D) RT-qPCR showing expression levels of 8 miRNAs in EPCs (C) and the plasma (D) of normal controls (PB) and CAD patients. *: p<0.05; **: p<0.01: ***: p<0.001 by Mann-Whitney U test.