Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza
Figure 8
Effects of DADA on survival rate, body weight, and food and water intake.
Mice infected with 60 pfu of IAV, representing the 50% lethal dose, were treated with oral DADA at 50 mg/kg, vehicle, or DCA administered peritoneally at 28 mg/kg at 12-h intervals for 14 days. The survival rate (A), body weight (B), food intake (C), and water intake (D) by infected mice were monitored. Differences in survival rate were analyzed by Kaplan-Meier and log-rank tests. Data are mean ± SD of 15 mice per group. *P<0.05, **P<0.01, vs. infected group treated with vehicle, by two-way ANOVA.