Telmisartan Activates Endothelial Nitric Oxide Synthase via Ser1177 Phosphorylation in Vascular Endothelial Cells
Figure 8
Telmisartan-induced NO production is suppressed by p38 MAPK inhibition.
Intracellular cGMP concentrations were measured to evaluate NO output from HUVECs treated with telmisartan after corrected for the protein concentration. HUVECs were incubated with vehicle (DMSO) or telmisartan (10 µM) for 2 h with or without SB202190 (10 µM) pretreatment for 30 min. nc, negative control. *, p < 0.01 versus nc + DMSO; #, p < 0.01 versus nc + telmisartan.