Addressing RNA Integrity to Determine the Impact of Mitochondrial DNA Mutations on Brain Mitochondrial Function with Age
Figure 3
RNA Error Frequency is Age-Independent in Controls but Elevated in Mutator Mice.
(A) mtRNA errors were measured as described at the same 7 loci as for mtDNA from brains of young (1 months, n = 8) and old (18 months, n = 8). (B) mtRNA errors in heterozygous (mut/+, n = 3) and homozygous (mut/mut, n = 3) mice. Figures show mean with SD. p**<0.01 vs. 18 months, p*< 0.05 vs. 18 months.