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Behavioral and Neural Correlates of Acute and Scheduled Hunger in C57BL/6 Mice

Figure 7

c-Fos protein expression in the in the nucleus accumbens core (NAc Core) of calorie-restricted, acutely fasted, and AL control mice.

(A) Representative micrographs of c-Fos staining in the core of the nucleus accumenbs at TP−1 and +2. (B) Mean (±SEM) number of c-Fos-immunoreactive nuclei in the NAc Core of AL, fasted, and CR mice at 5 time points measured relative to feeding. (C) Representative coronal brain map with Nissl stain showing location of region under study. (Adapted from Paxinos and Franklin). Sample sizes for TP−7.5 thru +2 are n = 4, 8, 8, 6, 4 for AL groups, n = 4, 8, 8, 6, 4 for CR groups, and n = 4, 4, 4, 4, 4 for Fast groups.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0095990.g007