Novel Antimicrobial Peptides That Inhibit Gram Positive Bacterial Exotoxin Synthesis
Figure 4
Exotoxin-synthesis-inhibition by hemoglobin-like synthetic peptides SP-1 (0% positively-charged amino acids), SP-2 (50% positively-charged amino acids), SP-3 (70% positively-charged amino acids) effects on S. aureus MNPE α-toxin production.
S. aureus MNPE cultures were incubated at 37°C for 9 h with shaking 200 revolutions per minute in the presence of indicated amounts of anti-infective peptides. Subsequently, α-toxin amounts were quantified by rabbit erythrocyte lysis. The dashed line indicates measured area of wells without α-toxin lysis.