Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy against a Murine Melanoma In Vivo
Figure 1
Genetic immunization with pSurv, along with rTcCRT, slows the growth of an experimental murine melanoma.
Mice were immunized with pSurv plasmid and then inoculated s.c. with PBS, rTcCRT or rHuCRT or each one of them alone. A: Time-course of the effects on tumor growth of the different treatments. B: Distribution measurements of solid tumors in each group, evaluated at day 18 (See A) after injection of tumor cells. C: Survival curve recorded as a percentage of surviving animals (those bearing 3,000 mm3 tumors were euthanized, according to bioethical considerations) until day 28 post-challenge with tumor cells. In A–C, the bottom panel shows p values (significant ones in bold) for all relevant comparisons.