Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies
Figure 3
(A) The number of significant SNs (size <50 and score>3) in Meta-GW (light green) and Meta-GATES (dark green) is shown compared with same values permuted across the FPAN: Meta-GW-Permuted (light grey) and Meta-GATES-Permuted (dark grey). (B) Score comparison of the top 10 SNs obtained in the corresponding module searches presented in (A). (C) The number of significant SNs in the replication step for ADNI-GW (light blue) and ADNI-GATES (dark blue) analysis, in comparison with their corresponding permuted controls: ADNI-GW-Permuted (light grey) and ADNI-GW-Permuted (dark grey). (D) Score comparison of the top 10 SNs obtained for each module searches presented in (C). Caped bar/points denote SD; Significant differences between real and permuted data observed in GW and GATES analysis are denoted by an asterisk and those between real and permuted data observed only in GW analysis are denoted by a plus sign (two-sided Student's t-test; p<0.01).