C/EBPδ Deficiency Sensitizes Mice to Ionizing Radiation-Induced Hematopoietic and Intestinal Injury
Figure 6
Cebpd−/− mice displayed increased loss of intestinal crypts in response to TBI.
Cebpd−/− and Cebpd+/+ mice were subjected to 0, 7.4, 8.5, and 10 Gy TBI, and tissues were obtained at day 3.5 post-irradiation. (A) Representative image of hematoxylin-eosin stained intestinal crypts in transverse sections (4X). (B) Using microcolony assays, surviving crypts from Cebpd +/+ and Cebpd−/− mice were scored. (C) Plasma citrulline levels in Cebpd−/− and Cebpd+/+ mice were determined before and 3.5 days after 8.5 Gy TBI. All data are presented as mean ± SEM, n = 4 mice per group. No IR: unirradiated; IR: irradiated.