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Effect of Needle Insertion Speed on Tissue Injury, Stress, and Backflow Distribution for Convection-Enhanced Delivery in the Rat Brain

Figure 6

Insertion speed dependence of infusion pressure for CED at 2 µL/min; A) typical pressure profiles during infusion; B) average peak, steady state pressure, and second peak () for varying needle insertion speeds.

(Bars indicate ±1 standard deviation; n = 8).

Figure 6

doi: https://doi.org/10.1371/journal.pone.0094919.g006