Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats
Figure 3
OVX enhanced formalin-induced nociceptive responses during phase 2 but did not affect CCI-induced mechanical allodynia.
(A) OVX rats showed a higher formalin pain scores during phase 2. * p<0.05, ** p<0.01 versus sham. (B) Subcutaneous injection of E2 (30 μg/day for 7 days) significantly suppressed formalin pain scores during phase 2. * p<0.05, ** p<0.01 versus vehicle control. E2 and vehicle were injected from the 4th week after OVX, and formalin test was performed at the 5th week. (C) Both sham-OVX and OVX groups developed mechanical allodynia on day 7 after CCI. There was no significant difference in PWTs between sham and OVX rats. CCI surgery was performed at 4 weeks after sham-OVX or OVX. ## p<0.01.