Major and Minor Group Rhinoviruses Elicit Differential Signaling and Cytokine Responses as a Function of Receptor-Mediated Signal Transduction
Figure 1
Major- and minor-group HRV produce distinct gene expression profiles in primary macrophages.
Human peripheral blood mononuclear cell-derived macrophages were exposed to HRV1A, HRV16, or mock at an MOI of 10 for 8 hours. Total RNA was extracted and ribosomal RNA was depleted and sequenced on the Illumina HiSeq platform. Raw read counts for were normalized to the transcript length and sequencing depth and quantile normalized. Gene expression profiles for macrophages exposed to A) HRV1A or B) HRV16 are presented as quantile normalized read counts per transcript per kb of transcript per million sequencing tags (RPKM), log2 scale.