Plasminogen Activator Inhibitor-1 Is Involved in Impaired Bone Repair Associated with Diabetes in Female Mice
Figure 4
Effects of PAI-1 deficiency on osteogenic differentiation during bone repair in female mice.
The levels of Runx2, Osterix, ALP, type I collagen (Col I), and osteocalcin (OCN) mRNA at the damaged site on day 7 after a femoral bone defect in female PAI-1+/+ and PAI-1−/− mice with or without STZ treatment. Data are expressed relative to GAPDH mRNA values, and are expressed as the mean ± SEM. *p<0.05, **p<0.01 (n = 5–7 in each group). Cont, control.