Endoplasmic Reticulum Stress-Mediated Activation of p38 MAPK, Caspase-2 and Caspase-8 Leads to Abrin-Induced Apoptosis
Figure 7
Role of p38MAPK, caspase-2 and caspase-8 on abrin-induced mitochondrial membrane potential (MMP) loss in Jurkat cells.
(A) Jurkat cells treated with abrin alone or along with inhibitors were harvested and stained with DiOC6 dye and the percentage of cells positive for green fluorescence were analyzed by flow cytometry as described in Materials and methods. The blue line indicates untreated Jurkat cells and the black line represents Jurkat cells treated as indicated in each panel. Also, percentage in each panel denotes the loss of mitochondrial membrane potential.