Dual Innervation of Neonatal Merkel Cells in Mouse Touch Domes
Figure 4
Merkel cell innervating Ret+ fibers show subtle phenotype in RetCFP/CFP mice.
A-B, Two examples of touch domes in control P0 RetCFP/+ mice. The back hairy skin sections were triple stained with antibodies against CK8, GFP and NFH. Ret+ fibers are indicated by red arrows, NFH+ fibers are indicated by green arrows, and the overlap spots of Ret+ and NFH+ fibers are indicated by yellow arrows. C-D, Two examples of touch domes in P0 RetCFP/CFP null mice. E, Quantification of touch dome Merkel innervation by NFH+ (P = 0.5723) and CFP+ (P = 0.1635) fibers in Ret null and control littermates. Scale bar, 20 μm. n = 3 for both genotypes. See also Table 1.